Discuss theories that may account for hemangioma-genesis. In the past, it was believed that a mother’s visual impressions or behavior during pregnancy caused the growth of infantile hemangioma in

If you google “infantile hemangioma placenta theory” you can read about several studies that link placental abnormalities (i.e. subchorionic hemorrhages) to the development of hemangioma birthmarks.

In their investigation of other tissues, the authors found that the placenta showed an identical phenotype with regard to these markers. 2 Further study has been carried out by Dr Carmen Barnes, working at Boston Children’s Hospital, who discovered that the placenta and the infantile hemangioma have high levels of transcriptome similarity when compared with normal skin and seven other normal Infantile haemangioma is usually a clinical diagnosis and investigations are not routinely indicated. Investigations may be considered if the diagnosis is uncertain, to define extent and associations, or monitor response to therapy. According to the intrinsic theory, infantile haemangioma originates from vasculogenesis, a process by which new blood vessels are formed.

Infantile hemangioma placenta theory

OBJECTIVES: This study aimed to verify whether the infantile hemangioma (IH) incidence in children whose placentas showed a chorangioma is higher than in the general population, thus addressing the hypothesized relationship between chorangioma and IH. Infantile hemangioma (IH) is the currently accepted terminology for the lesions that are the focus of this clinical report. Congenital hemangiomas are biologically and behaviorally distinct from IH. Pyogenic granuloma is a reactive proliferating vascular lesion that is classified as a vascular neoplasm and that may occasionally be misdiagnosed as IH. of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that have suggested this pos-sibility [North, P. E., et al. (2001) Arch. Dermatol. 137, 559-570].

If you google “infantile hemangioma placenta theory” you can read about several studies that link placental abnormalities (i.e. subchorionic hemorrhages) to the development of hemangioma birthmarks.

Background: The unique immunobiology of the placental trophoblast and the increased incidence of hemangiomas in infants born after chorionic villus sampling suggest that an immunologically regulated ectopic focus of trophoblasts could be the cell of origin for proliferative infantile hemangiomas. Objective: To compare tissue from infantile hemangiomas with that of other vascular lesions for the presence of selected placental trophoblast-specific cellular markers. The higher ratio of placental pathologic findings in patients with infantile hemangioma suggests that reduced placental oxygen diffusive conductance contributes to fetal hypoxic stress and that hypoxic/ischemic changes in the placenta could be related to infantile hemangioma development via vascular endothelial growth factor and placental growth factor expression, among others, within the villious vessels and throphoblasts.

Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells. Stem Cells Dayt Ohio 33(1): 133-145. 11. Sagi L, Zvulunov A, Lapidoth M, Ben Amitai D (2014) Efficacy and safety of propranolol for the treatment of infantile hemangioma: a presentation of ninety-nine cases.

Therefore, embolization theory are the failed attempts to detect the presence of maternal–fetal chimerism in IH tissue[28]. 2001-03-15 The relative incidence of hemangioma among infants with lower birth weights climbs to 22% especially among infants having less than 1.5 kg of birth weight [4]. The risk of developing infantile hemangioma is relatively increased with older maternal age, uncontrolled preeclampsia, and maternal placenta previa [5]. 2010-03-17 This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. Special emphasis will be placed on placental vasculogenesis and the presence and transit of placental progenitor cells during gestation.

2010-03-17 This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. Special emphasis will be placed on placental vasculogenesis and the presence and transit of placental progenitor cells during gestation. This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma.
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Although benign, infants with IH can experience complications including ulceration, visual and airway impairment, and residual scarring and disfigurement. It is often challenging for clinicians to predict which tumors are in need of systemic treatment.

If the hypothesis proves to be valid, clues for possible treatment are outlined.
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2008-04-25

Fluorescent in situ hybridization on surgical specimens of proliferating hemangiomas (n=8) demonstrated no XX-labeled HEC from resected tumors of male infants. A hemangioma or haemangioma is a usually benign vascular tumor derived from blood vessel cell types. The most common form is infantile hemangioma, known colloquially as a "strawberry mark", most commonly seen on the skin at birth or in the first weeks of life.A hemangioma can occur anywhere on the body, but most commonly appears on the face, scalp, chest or back. We know that they are not inherited and, unlike infantile haemangiomas, they affect males and females equally.